January 12th, 2017 11.00 - 12.30
Intelligent Biomaterials to Control Recognition and Specificity in Nanomedicine
Nicholas A Peppas, Sc.D.
Cockrell Family Regents Chair in Engineering
Director, Institute of Biomaterials, Drug Delivery and Regenerative Medicine
Professor, Department of Biomedical Engineering, Department of Chemical Engineering,
Department of Surgery and Perioperative Care, Dell Medical School,
and Division of Pharmaceutics, College of Pharmacy
The University of Texas at Austin
Austin, TX 78712, USA
The development of molecularly imprinted polymers using solution-compatible production methods enables the possibility to further exploit this technology for chemical separations and biomedical applications. The field of biomaterials provides the foundations for the investigation and development of novel nano- and microstructures for recognitive and physiologically-responsive systems, diagnostic devices, biosensors and combination products. New design methods for intelligent materials have allowed a wide range of chemical, separation and biomedical applications. Indeed, engineering the molecular design of intelligent hydrogels by controlling recognition and specificity is the first step in coordinating and duplicating complex chemical and physiological processes. We address design and synthesis characteristics of novel crosslinked networks capable of desirable interactions with surrounding fluids. We also discuss the dynamic behavior of artificial molecular structures capable of specific molecular recognition of biological molecules. We will also discuss recent studies on intelligent polymer carriers for solute delivery to specific sites, using responsive polymers to achieve pH- or temperature-triggered devices, usually in modulated mode, and improvement of the behavior of their adhesive behavior. New methods of molecular imprinting and micro-imprinting, which create stereo-specific three-dimensional binding cavities based on a compound of interest can lead to preparation of mimetic materials for intelligent materials engineering.
Nicholas A. Peppas is the Cockrell Family Regents Chaired Professor in the Departments of Chemical, Biomedical Engineering, Surgery in the Dell Medical School, and Pharmacy, and Director of the Institute of Biomaterials, Drug Delivery and Regenerative Medicine of the University of Texas at Austin. His work in biomaterials, drug delivery, regenerative medicine and bionanotechnology follows a multidisciplinary approach by blending modern molecular and cellular biology with engineering principles to design the next-generation of medical systems and devices for patient treatment. Over the past 40 years he has set the fundamentals and rational design of drug delivery systems and developed models of drug and protein diffusion in controlled release devices and biological tissues. In 2012 he received the Founders Award of the National Academy of Engineering (NAE), the highest recognition of the Academy, for these contributions to the field. Peppas is a member of the NAE, National Academy of Medicine, National Academy of Inventors, the National Academy of France, the Royal Academy of Spain, the Academy of Athens (Greece) and the Academy of Texas. He has been recognized with awards from AIChE (Founders Award, William Walker Award, Institute Lecture, Jay Bailey Award, Bioengineering Award, Materials Award), the Biomedical Engineering Society (Distinguished Scientist Award), the American Institute of Medical and Biological Engineering (Galletti Award), the Society for Biomaterials (Founders, Clemson and Hall Awards), the Controlled Release Society (Founders, Heller and Eurand Awards) and other societies. In 2008, AIChE named him on of the One Hundred Chemical Engineers of the Modern Era. He is President of the International Union of Societies of Biomaterials Science and Engineering, Chair of the Engineering Section of the American Association for the Advancement of Science, and Past-Chair of the Council of BME Chairs. Previously, he served as President of SFB and the Controlled Release Society. He is a fellow of AAAS, AIChE, APS, ACS, MRS, SFB, BMES, AIMBE, CRS, AAPS, and ASEE. He has supervised the research of more than 100 PhDs and about 180 postdocs and graduate students. Peppas holds a Dipl. Eng. from the NTU of Athens (1971), a Sc.D. from MIT (1973), and honorary doctorates from the Universities of Ghent, Parma, Athens, Ljubljana and Patras, and an honorary professorship from Sichuan University.
How to get to the venue: from metro and train stations "Lambrate"