Seminar: Combinatorial Nanonconstructs for Imaging and Treating Cancer and Inflammatory Diseases

Combinatorial Nanonconstructs for Imaging and Treating Cancer and Inflammatory Diseases

Speaker:

Speaker: Prof. Paolo Decuzzi
Laboratory of Nanotechnology for Precision Medicine
Italian Institute of Technology – Genova
https://www.iit.it/research/lines/nanotechnology-for-precision-medicine

Abstract:

Multifunctional nanoconstructs are particle-based nano-scale systems designed for the ‘smart’
delivery of therapeutic and imaging agents. The Laboratory of Nanotechnology for Precision
Medicine at IIT-GE synthesizes polymeric nanoconstructs with different sizes, ranging from a
few tens of nanometers to a few microns; shapes, including spherical, cubical and discoidal;
surface properties, with positive, negative, neutral coatings; and mechanical stiffness, varying
from that of cells to rigid, inorganic materials, such as iron oxide. These are the 4S parameters
– size, shape, surface, stiffness – which can be precisely tuned in the synthesis process
enabling disease- and patient-specific designs of multifunctional nanoconstructs. In this
lecture, the role of manipulating these 4S parameters